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Zorzi, Alessandro, MD; ElMaghawry, Mohamed, MD; Rigato, Ilaria, MD, PhD; Cardoso Bianchini, Fernando, MD; Crespi Ponta, Georgiane, MD; Michieli, Pierantonio, MD, PhD; Migliore, Federico, MD, PhD; Perazzolo Marra, Martina, MD, PhD; Bauce, Barbara, MD, PhD; Basso, Cristina, MD, PhD; Schiavon, Maurizio, MD; Thiene, Gaetano, MD; Iliceto, Sabino, MD; Corrado, Domenico, MD, PhD
The American journal of cardiology, 08/2013, Letnik: 112, Številka: 3Journal Article
Negative T waves (NTWs) in right precordial leads (V1 to V3 ) may be observed on the electrocardiogram (ECG) of healthy subjects but can also represent the hallmark of an underlying arrhythmogenic right ventricular cardiomyopathy (ARVC). It has been a consistent observation that NTWs usually become upright with exercise in healthy subjects without underlying heart disease. No systematic study has evaluated exercise-induced changes of NTWs in ARVC. We assessed the prevalence and relation to the clinical phenotype of exercise-induced right precordial NTWs changes in 35 patients with ARVC (19 men, mean age 22.2 ± 6.2 years). Forty-one healthy subjects with right precordial NTWs served as controls. At peak of exercise (mean power 149 ± 43 W, mean heart rate 83.6 ± 12.6% of target), NTWs persisted in 3 patients with ARVC (9%), completely normalized in 12 (34%), and partially reverted in 20 (57%). Patients with ARVC with or without NTWs normalization showed a similar clinical phenotype. The overall prevalence of right precordial T waves changes during exercise (normalization plus partial reversal) did not differ between patients with ARVC and controls (92% vs 88%, p = 1.0), whereas there was a statistically nonsignificant trend toward a greater prevalence of complete normalization in controls (56% vs 34%, p = 0.06). In conclusion, our study demonstrated that right precordial NTWs partially or completely revert with exercise in most patients with ARVC, and NTWs normalization is unrelated to the clinical phenotype. Exercise-induced NTWs changes are inaccurate in differentiating between ARVC patients and benign repolarization abnormalities.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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