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Magistrelli, Luca; Contaldi, Elena; Vignaroli, Francesca; Gallo, Silvia; Colombatto, Federico; Cantello, Roberto; Comi, Cristoforo
International journal of molecular sciences, 03/2022, Letnik: 23, Številka: 7Journal Article
Parkinson's disease (PD) is a common neurodegenerative disease characterized by loss of dopaminergic neurons in the of the midbrain . PD pathophysiology is complex, multifactorial, and not fully understood yet. Nonetheless, recent data show that immune system hyperactivation with concomitant production of pro-inflammatory cytokines, both in the central nervous system (CNS) and the periphery, is a signature of idiopathic PD. About 5% of PD patients present an early onset with a determined genetic cause, with either autosomal dominant or recessive inheritance. The involvement of immunity in the genetic forms of PD has been a matter of interest in several recent studies. In this review, we will summarize the main findings of this new and promising field of research.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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