Given the high rates of maladjustment among children of depressed mothers, parenting is likely to cause significant life stress in this population, potentially worsening the course of mothers’ depression. The present study is a comparison of severe life stress in 38 mothers and 62 non‐mothers receiving treatment for recurrent major depression. Life stress was assessed using the Life Events and Difficulties Schedule Brown and Harris, 1978a. We hypothesized that mothers would evidence a greater number of severe life events and marked difficulties both in the year prior to the onset of their depressive index episode and in the time period following the onset of their current depressive episode. Prior to depression onset, mothers reported a significantly greater number of entrapping difficulties, but not marked difficulties, severe events, entrapping events, or humiliating events. However, following the onset of depression, mothers experienced a significantly greater number of severe events, entrapping events, marked difficulties, and entrapping difficulties, but not humiliating events. Mothers’ elevated levels of stress were attributable to child‐related stress, predominantly related to children’s psychological and behavioral problems. Our findings suggest that comprehensive treatment for mothers with major depression needs to address their parenting style and any psychological problems experienced by their children. Depression and Anxiety 13:109–117, 2001. © 2001 Wiley‐Liss, Inc.