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Zeng, Yao-fu; Wu, Jia-qiang; Shi, Lian-yong; Wang, Ke; Zhou, Bin; Tang, Yong; Zhang, Da-yong; Wu, Yang-chang; Hua, Wei-yi; Wu, Xiao-ming
Bioorganic & medicinal chemistry letters, 03/2012, Letnik: 22, Številka: 5Journal Article
A series of tetracyclic diterpenoids bearing α-methylenelactone group were synthesized from stevioside. Some of them exhibited significant cytotoxicity against all the six tumor cell lines with the IC50 values ranging from 0.09 to 5.71μM. A series of tetracyclic diterpenoids bearing the α-methylenelactone group have been synthesized and screened for their in vitro anti-tumor activities against six human cancer cell lines. The results showed that compounds 1c, 2a and 2b exhibited significant cytotoxicity superior to the positive control doxorubicin hydrochloride against MDA-MB-231, K562 and HepG2 cell lines. In particular, compound 2b was identified as the most promising anticancer agent against HepG2 cells with IC50 value of 0.09μM.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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