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Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysisLEE, Yi-Ching; KUO, Ho-Chang; HUANG, Yhu-Chering; HWANG, Betau; CHIU, Nan-Chang; HWANG, Kao-Pin; LEE, Pi-Chang; CHANG, Li-Ching; LIU, Yi-Min; CHEN, Ying-Ju; CHEN, Chien-Hsiun; PEDIATRIC, Taiwan; CHANG, Jeng-Sheng; CHEN, Yuan-Tsong; TSAI, Fuu-Jen; WU, Jer-Yuarn; CHANG, Luan-Yin; HUANG, Li-Min; CHEN, Ming-Ren; LIANG, Chi-Di; CHI, Hsin; HUANG, Fu-Yuan; LEE, Meng-Luen
Nature genetics, 05/2012, Letnik: 44, Številka: 5Journal Article
To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10(-8)). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis.
