E-viri
PDF
Recenzirano
Odprti dostop
-
Pharoah, Paul D P; Bolton, Kelly L; Tyrer, Jonathan; Ramus, Susan J; Notaridou, Maria; Jones, Chris; Sher, Tanya; Gentry-Maharaj, Aleksandra; Wozniak, Eva; Tsai, Ya-Yu; Weidhaas, Joanne; Paik, Daniel; Van Den Berg, David J; Stram, Daniel O; Pearce, Celeste Leigh; Wu, Anna H; Brewster, Wendy; Anton-Culver, Hoda; Ziogas, Argyrios; Narod, Steven A; Levine, Douglas A; Kaye, Stanley B; Brown, Robert; Paul, Jim; Sieh, Weiva; McGuire, Valerie; Whittemore, Alice S; Gore, Martin E; Lissowska, Jolanta; Yang, Hanna P; Medrek, Krzysztof; Gronwald, Jacek; Lubinski, Jan; Jakubowska, Anna; Le, Nhu D; Cook, Linda S; Kelemen, Linda E; Massuger, Leon F A G; Kiemeney, Lambertus A; van Altena, Anne M; Houlston, Richard; Tomlinson, Ian; Palmieri, Rachel T; Moorman, Patricia G; Iversen, Edwin S; Phelan, Catherine; Vierkant, Robert A; Cunningham, Julie M; Goode, Ellen L; Fridley, Brooke L; Kruger-Kjaer, Susan; Blaeker, Jan; Hogdall, Estrid; Hogdall, Claus; Gross, Jenny; Karlan, Beth Y; Ness, Roberta B; Edwards, Robert P; Odunsi, Kunle; Moyisch, Kirsten B; Baker, Julie A; Modugno, Francesmary; Heikkinenen, Tuomas; Nevanlinna, Heli; Leminen, Arto; Antonenkova, Natalia; Hillemanns, Peter; Dürst, Matthias; Runnebaum, Ingo; Thompson, Pamela J; Carney, Michael E; Lurie, Galina; Hein, Rebecca; Chang-Claude, Jenny; Rossing, Mary Anne; Doherty, Jennifer; Chen, Chu; Rafnar, Thorunn; Besenbacher, Soren; Sulem, Patrick; Stefansson, Kari; Terry, Kathryn L; Hernandez, Dena; Cramer, Daniel W; Vergote, Ignace; Amant, Frederic; Despierre, Evelyn; Fasching, Peter A; Beckmann, Matthias W; Thiel, Falk C; Chen, Xiaoqing; Johnatty, Sharon E; Webb, Penelope M; Beesley, Jonathan; Chanock, Stephen; Garcia-Closas, Montserrat; Sellers, Tom; Easton, Douglas F; Berchuck, Andrew; Gayther, Simon A
Nature genetics, 10/2010, Letnik: 42, Številka: 10Journal Article
Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 × 10−4 and P = 6 × 10−4, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3 × 10−9 and P = 4 × 10−11, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.
