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Wang, Ruobing; Doolan, Denise L.; Le, Thong P.; Hedstrom, Richard C.; Coonan, Kevin M.; Charoenvit, Yupin; Jones, Trevor R.; Hobart, Peter; Margalith, Michal; Ng, Jennifer; Weiss, Walter R.; Sedegah, Martha; de Taisne, Charles; Norman, Jon A.; Hoffman, Stephen L.
Science (American Association for the Advancement of Science), 10/1998, Letnik: 282, Številka: 5388Journal Article
CD8$^+$ cytotoxic T lymphocytes (CTLs) are critical for protection against intracellular pathogens but often have been difficult to induce by subunit vaccines in animals. DNA vaccines elicit protective CD8$^+$ T cell responses. Malaria-naïve volunteers who were vaccinated with plasmid DNA encoding a malaria protein developed antigen-specific, genetically restricted, CD8$^+$ T cell-dependent CTLs. Responses were directed against all 10 peptides tested and were restricted by six human lymphocyte antigen (HLA) class I alleles. This first demonstration in healthy naive humans of the induction of CD8$^+$ CTLs by DNA vaccines, including CTLs that were restricted by multiple HLA alleles in the same individual, provides a foundation for further human testing of this potentially revolutionary vaccine technology.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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