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Berrino, Franco; Zeleniuch-Jacquotte, Anne; Bracci, Paige M; Buring, Julie E; Fuchs, Charles S; Berg, Christine D; Trichopoulos, Dimitrios; Michaud, Dominique S; Chanock, Stephen J; Klein, Alison P; Hartge, Patricia; Jackson, Rebecca; Amundadottir, Laufey; Jacobs, Kevin B; LaCroix, Andrea; Van Den Eeden, Stephen K; Tobias, Geoffrey S; Gallinger, Steven; Holly, Elizabeth A; McWilliams, Robert R; Li, Donghui; Mendelsohn, Julie B; Olson, Sara H; Bamlet, William; Clavel-Chapelon, Françoise; Patel, Alpa V; Hunter, David J; Hutchinson, Amy; Kraft, Peter; Peeters, Petra H M; González, Carlos A; Wolpin, Brian M; Cotterchio, Michelle; Arslan, Alan A; Wactawski-Wende, Jean; Gaziano, J Michael; Riboli, Elio; Virtamo, Jarmo; Kaaks, Rudolf; Overvad, Kim; Jacobs, Eric J; Goggins, Michael; Zheng, Wei; Jenab, Mazda; Giovannucci, Edward L; Stolzenberg-Solomon, Rachael Z; Hallmans, Göran; Canzian, Federico; Duell, Eric J; Kurtz, Robert C; Lynch, Shannon M; Mandelson, Margaret; Hassan, Manal; de Andrade, Mariza; Bingham, Sheila; Kooperberg, Charles; Helzlsouer, Kathy; Yu, Herbert; Gross, Myron; Petersen, Gloria M; Risch, Harvey A; Shu, Xiao-Ou; Hoover, Robert N; Rajkovic, Aleksandar; Clipp, Sandra; Fox Jr, John W; Hankinson, Susan E; Yu, Kai; Bueno-de-Mesquita, H Bas; Albanes, Demetrius; Thomas, Gilles
Nature genetics, 09/2009, Letnik: 41, Številka: 9Journal Article
We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 × 10−8; multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.
