E-viri
Recenzirano
Odprti dostop
-
Harris, Sarah E; Hagenaars, Saskia P; Ritchie, Stuart J; Marioni, Riccardo E; Fawns-Ritchie, Chloe; Liewald, David C M; Barnes, Catriona L K; Bertram, Lars; Bis, Joshua C; Christoforou, Andrea; DeRosse, Pamela; Djurovic, Srdjan; Espeseth, Thomas; Hayward, Caroline; Hofer, Edith; Ikram, M Arfan; Knowles, Emma; Melle, Ingrid; Morris, Derek; Oldmeadow, Christopher; Payton, Antony; Pazoki, Raha; Scholz, Markus; Windham, B Gwen; Wright, Margaret J; Amin, Najaf; Amouyel, Philippe; Armstrong, Nicola J; Bennett, David A; Boyle, Patricia A; Campbell, Harry; Cirulli, Elizabeth T; Conley, Emily Drabant; Cox, Simon R; Dale, Anders M; Dehghan, Abbas; Eriksson, Johan G; Evangelou, Evangelos; Faul, Jessica D; Gao, He; Giegling, Ina; Gillespie, Nathan A; Gottesman, Rebecca F; Gudnason, Vilmundur; Harris, Tamara B; Holliday, Elizabeth G; Kähönen, Mika; Kleineidam, Luca; Kwok, John B; Le Hellard, Stephanie; Lehtimäki, Terho; Lill, Christina M; Liu, Tian; Lopez, Oscar L; Loukola, Anu; Lundervold, Astri J; Lundquist, Anders; Lyytikäinen, Leo-Pekka; Murray, Alison D; Need, Anna C; Ollier, William; Psaty, Bruce M; Reppermund, Simone; Roussos, Panos; Saba, Yasaman; Satizabal, Claudia L; Smyrnis, Nikolaos; Soumaré, Aïcha; Stefanis, Nikos C; Straub, Richard E; Sundet, Kjetil; Taylor, Adele M; Tzourio, Christophe; Uitterlinden, André; Voineskos, Aristotle N; Wagner, Holger; Zhao, Wei; Bilder, Robert M; Bitsios, Panos; De Jager, Philip L; Donohoe, Gary; Elliott, Paul; Fitzpatrick, Annette L; Glahn, David C; Ikram, M Kamran; Vuoksimaa, Eero; Launer, Lenore; Lindenberger, Ulman; Porteous, David J; Ramirez, Alfredo; Reinvang, Ivar; Schmidt, Helena; Schofield, Peter R; Weir, David R; Wilson, James F; McIntosh, Andrew M; Seshadri, Sudha; Mosley, Jr, Thomas H; Lencz, Todd; Deary, Ian J
Nature communications, 05/2018, Letnik: 9, Številka: 1Journal Article
General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10 ) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.