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van Doremalen, Neeltje; Letko, Michael; Fischer, Robert J; Bushmaker, Trenton; Schulz, Jonathan; Yinda, Claude K; Seifert, Stephanie N; Kim, Nam Joong; Hemida, Maged G; Kayali, Ghazi; Park, Wan Beom; Perera, Ranawaka A P M; Tamin, Azaibi; Thornburg, Natalie J; Tong, Suxiang; Queen, Krista; van Kerkhove, Maria D; Choi, Young Ki; Oh, Myoung-Don; Assiri, Abdullah M; Peiris, Malik; Gerber, Susan I; Munster, Vincent J
Emerging infectious diseases, 12/2021, Letnik: 27, Številka: 12Journal Article
Middle East respiratory syndrome coronavirus (MERS-CoV) infects humans and dromedary camels and is responsible for an ongoing outbreak of severe respiratory illness in humans in the Middle East. Although some mutations found in camel-derived MERS-CoV strains have been characterized, most natural variation found across MERS-CoV isolates remains unstudied. We report on the environmental stability, replication kinetics, and pathogenicity of several diverse isolates of MERS-CoV, as well as isolates of severe acute respiratory syndrome coronavirus 2, to serve as a basis of comparison with other stability studies. Although most MERS-CoV isolates had similar stability and pathogenicity in our experiments, the camel-derived isolate C/KSA/13 had reduced surface stability, and another camel isolate, C/BF/15, had reduced pathogenicity in a small animal model. These results suggest that although betacoronaviruses might have similar environmental stability profiles, individual variation can influence this phenotype, underscoring the need for continual global viral surveillance.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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