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Heijnen, Nanon F. L.; Hagens, Laura A.; Smit, Marry R.; Cremer, Olaf L.; Ong, David S. Y.; van der Poll, Tom; van Vught, Lonneke A.; Scicluna, Brendon P.; Schnabel, Ronny M.; van der Horst, Iwan C. C.; Schultz, Marcus J.; Bergmans, Dennis C. J. J.; Bos, Lieuwe D. J.; de Beer, Friso M.; Bos, Lieuwe D.; Glas, Gerie J.; Horn, Janneke; Hoogendijk, Arie J.; van Hooijdonk, Roosmarijn T.; Huson, Mischa A.; van der Poll, Tom; Scicluna, Brendon; Schouten, Laura R.; Schultz, Marcus J.; Straat, Marleen; van Vught, Lonneke A.; Wieske, Luuk; Wievel, Maryse A.; Witteveen, Esther; Bonten, Marc J.; Cremer, Olaf L.; Frencken, Jos F.; van de Groep, Kirsten; Klein Klouwenberg, Peter M.; Koster-Brouwer, Maria E.; Ong, David S.; Varkila, Meri R.; Verboom, Diana M.
American journal of respiratory and critical care medicine, 06/2021, Letnik: 203, Številka: 12Journal Article
Heijnen et al discuss their study which aim to determine whether these subphenotypes and their prognostic and potential for predictive enrichment could be extended to other patients in the ICU, irrespective of fulfilling the definition of acute respiratory distress syndrome (ARDS). This is a secondary analysis of a prospective observational study of adult patients admitted to the ICU. We tested the prognostic enrichment of both cluster-derived and latent-class analysis (LCA)-derived biological ARDS subphenotypes by evaluating the association with clinical outcome (ICU-day, 30-day mortality, and ventilator-free days) using logistic regression and Cox regression analysis. We performed a principal component analysis to compare blood leukocyte gene expression profiles between subphenotypes and the presence of ARDS. The results revealed that the prognostic and potential for predictive enrichment of biological ARDS subphenotypes may be extended to mechanically ventilated critically ill patients without ARDS.
