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Saloner, Rowan; Paolillo, Emily W.; Heaton, Robert K.; Grelotti, David J.; Stein, Murray B.; Miller, Andrew H.; Atkinson, J. Hampton; Letendre, Scott L.; Ellis, Ronald J.; Grant, Igor; Iudicello, Jennifer E.; Moore, David J.
Journal of neurovirology, 02/2021, Letnik: 27, Številka: 1Journal Article
We examined the joint effects of depressive symptoms (Beck Depression Inventory-II (BDI-II)) and systemic inflammation (plasma C-reactive protein (CRP)) on longitudinal profiles of neurocognition in a cohort of 143 people with HIV (PWH) on antiretroviral therapy. Global neurocognition, processing speed, motor skills, and attention/working memory all worsened as CRP increased but only among PWH who, on average, exhibited moderate to severe depressive symptoms (BDI-II > 22). Findings suggest that some PWH with chronically elevated depressive symptoms may have an inflammatory subtype of depression and a particular vulnerability to neurocognitive changes that may respond to drugs targeting inflammation or its neural sequelae.
