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SARS-CoV-2 breakthrough infections elicit potent, broad, and durable neutralizing antibody responsesWalls, Alexandra C.; Sprouse, Kaitlin R.; Bowen, John E.; Joshi, Anshu; Franko, Nicholas; Navarro, Mary Jane; Stewart, Cameron; Cameroni, Elisabetta; McCallum, Matthew; Goecker, Erin A.; Degli-Angeli, Emily J.; Logue, Jenni; Greninger, Alex; Corti, Davide; Chu, Helen Y.; Veesler, David
Cell, 03/2022, Letnik: 185, Številka: 5Journal Article
Although infections among vaccinated individuals lead to milder COVID-19 symptoms relative to those in unvaccinated subjects, the specificity and durability of antibody responses elicited by breakthrough cases remain unknown. Here, we demonstrate that breakthrough infections induce serum-binding and -neutralizing antibody responses that are markedly more potent, durable, and resilient to spike mutations observed in variants than those in subjects who received only 2 doses of vaccine. However, we show that breakthrough cases, subjects who were vaccinated after infection, and individuals vaccinated three times have serum-neutralizing activity of comparable magnitude and breadth, indicating that an increased number of exposures to SARS-CoV-2 antigen(s) enhance the quality of antibody responses. Neutralization of SARS-CoV was moderate, however, underscoring the importance of developing vaccines eliciting broad sarbecovirus immunity for pandemic preparedness. Display omitted •Breakthrough infections induce potent neutralizing antibody responses•Number of exposures (infection or vaccination) correlates with potency and breadth•Three-dose vaccination improves neutralization of the SARS-CoV-2 Omicron variant•SARS-CoV-2 infection or vaccination elicit moderate neutralization of SARS-CoV Individuals with breakthrough COVID-19 infections, previously infected/vaccinated individuals, and those vaccinated thrice have potent serum-binding and -neutralizing antibody responses against variants of concern, including Omicron. Neutralization of SARS-CoV, however, was moderate, thus urging the need for developing broad vaccines for pandemic preparedness.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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