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Filbin, Mariella G; Tirosh, Itay; Hovestadt, Volker; Shaw, McKenzie L; Escalante, Leah E; Mathewson, Nathan D; Neftel, Cyril; Frank, Nelli; Pelton, Kristine; Hebert, Christine M; Haberler, Christine; Yizhak, Keren; Gojo, Johannes; Egervari, Kristof; Mount, Christopher; van Galen, Peter; Bonal, Dennis M; Nguyen, Quang-De; Beck, Alexander; Sinai, Claire; Czech, Thomas; Dorfer, Christian; Goumnerova, Liliana; Lavarino, Cinzia; Carcaboso, Angel M; Mora, Jaume; Mylvaganam, Ravindra; Luo, Christina C; Peyrl, Andreas; Popović, Mara; Azizi, Amedeo; Batchelor, Tracy T; Frosch, Matthew P; Martinez-Lage, Maria; Kieran, Mark W; Bandopadhayay, Pratiti; Beroukhim, Rameen; Fritsch, Gerhard; Getz, Gad; Rozenblatt-Rosen, Orit; Wucherpfennig, Kai W; Louis, David N; Monje, Michelle; Slavc, Irene; Ligon, Keith L; Golub, Todd R; Regev, Aviv; Bernstein, Bradley E; Suvà, Mario L
Science (American Association for the Advancement of Science), 04/2018, Letnik: 360, Številka: 6386Journal Article
Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily in the midline of the central nervous system of young children, suggesting a cooperation between genetics and cellular context in tumorigenesis. Although the genetics of H3K27M-glioma are well characterized, their cellular architecture remains uncharted. We performed single-cell RNA sequencing in 3321 cells from six primary H3K27M-glioma and matched models. We found that H3K27M-glioma primarily contain cells that resemble oligodendrocyte precursor cells (OPC-like), whereas more differentiated malignant cells are a minority. OPC-like cells exhibit greater proliferation and tumor-propagating potential than their more differentiated counterparts and are at least in part sustained by signaling. Our study characterizes oncogenic and developmental programs in H3K27M-glioma at single-cell resolution and across genetic subclones, suggesting potential therapeutic targets in this disease.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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