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Zhang, Yang W.; Wang, Zhihong; Xie, Wenbing; Cai, Yi; Xia, Limin; Easwaran, Hariharan; Luo, Jianjun; Yen, Ray-Whay Chiu; Li, Yana; Baylin, Stephen B.
Molecular cell, 01/2017, Letnik: 65, Številka: 2Journal Article
TET proteins, by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), are hypothesized, but not directly shown, to protect promoter CpG islands (CGIs) against abnormal DNA methylation (DNAm) in cancer. We define such a protective role linked to DNA damage from oxidative stress (OS) known to induce this abnormality. TET2 removes aberrant DNAm during OS through interacting with DNA methyltransferases (DNMTs) in a “Yin-Yang” complex targeted to chromatin and enhanced by p300 mediated TET2 acetylation. Abnormal gains of DNAm and 5hmC occur simultaneously in OS, and knocking down TET2 dynamically alters this balance by enhancing 5mC and reducing 5hmC. TET2 reduction results in hypermethylation of promoter CGIs and enhancers in loci largely overlapping with those induced by OS. Thus, TET2 indeed may protect against abnormal, cancer DNAm in a manner linked to DNA damage. Display omitted •TET2 is acetylated at K110 by p300 and deacetylated by HDAC1/2•Acetylation increases TET2 activity, protein stability, and partnering with DNMT1•Oxidative stress targets TET2/DNMTs to chromatin, increases DNAm and 5hmC•TET2 KO induces DNA hypermethylation in a manner similar to oxidative stress TETs trigger active DNA demethylation by converting 5mC to 5hmC, and dysfunction of TET2 is frequently observed in cancers. Zhang et al. define a TET2-DNMTs “Yin-Yang” complex that is targeted to chromatin during oxidative stress to prevent abnormal DNA methylation and identify a post-translational modification that positively regulates this process.
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