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Au, Lewis; Hatipoglu, Emine; Litchfield, Kevin; Beattie, Gordon; Horswell, Stuart; Nicol, David; Mason, Robert; Del Rosario, Lyra; Edmonds, Kim; Lingard, Karla; Sarker, Sarah; Carlyle, Eleanor; Attig, Jan; Becker, Pablo D.; Puccio, Ignazio; Lund, Tom; Ghorani, Ehsan; Xu, Hang; Mitchison, Miriam; Moore, David A.; Proctor, Ian; Falzon, Mary; Furness, Andrew J.S.; Reading, James L.; Marafioti, Teresa; Abbosh, Chris; Bridgewater, John; Hochhauser, Daniel; Forster, Martin; Enfield, Katey; Huebner, Ariana; Enver, Tariq; Sinclair, Ron; Rhodes, Zoe; Moore, David; Khiroya, Reena; Ellery, Peter; Veeriah, Selvaraju; Shaw, Heather; Attard, Gert; Akther, Mita Afroza; Naceur-Lombardelli, Cristina; Manzano, Lizi; Summan, Simranpreet; Kanu, Nnenna; Ward, Sophie; Stone, Paddy; Stirling, Caroline; Spain, Lavinia; Shum, Ben; Carlyle, Eleanor; Korteweg, Justine; Chandra, Ashish; Stewart, Ruby; Iredale, Lara-Rose; Enting, Debra; Ghosh, Sharmistha; Karapagniotou, Lena; Pintus, Elias; Tutt, Andrew; Howlett, Sarah; Michalarea, Vasiliki; Caldas, Carlos; Fitzgerald, Rebecca; Provenzano, Elena; Cluroe, Alison; McDermott, Ultan; Tavare, Simon; Roxburgh, Patricia; Chalmers, Anthony; Fraser, Sioban; Oien, Karin; Krebs, Matt; Blackhall, Fiona; Dransfield, Jo; Le Quesne, John; Tanchel, Bruce; Langman, Gerald; Robinson, Andrew; Kerr, Amy; Middleton, Gary; Webb, Joanne; Ottensmeier, Christian; Harrison, David; Hackshaw, Allan; Ledermann, Jonathan; Sharp, Abby; Farrelly, Laura; Bridger, Hayley; Kassiotis, George; Chain, Benny; Larkin, James; Swanton, Charles; Quezada, Sergio A.; Turajlic, Samra; Drake, William; Fernando, Archana; Hazell, Steve; Hill, Peter; O'Brien, Tim
Cancer cell, 11/2021, Letnik: 39, Številka: 11Journal Article
ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma (ccRCC) aiming to understand the mechanism underpinning therapeutic response. Genomic analyses show no correlation between tumor molecular features and response, whereas ccRCC-specific human endogenous retrovirus expression indirectly correlates with clinical response. T cell receptor (TCR) analysis reveals a significantly higher number of expanded TCR clones pre-treatment in responders suggesting pre-existing immunity. Maintenance of highly similar clusters of TCRs post-treatment predict response, suggesting ongoing antigen engagement and survival of families of T cells likely recognizing the same antigens. In responders, nivolumab-bound CD8+ T cells are expanded and express GZMK/B. Our data suggest nivolumab drives both maintenance and replacement of previously expanded T cell clones, but only maintenance correlates with response. We hypothesize that maintenance and boosting of a pre-existing response is a key element of anti-PD-1 mode of action. Display omitted •115 pre- and post-nivolumab multiregion tumor samples in a prospective phase II study•Maintenance of pre-treatment expanded TCR clones associates with response•Expanded CD8+ T cells upregulate GZMB/K in responders•HERV expression reflects tumor purity and indirectly correlates with response ADAPTeR is a phase II study of nivolumab (anti-PD-1) in treatment-naive patients with metastatic clear cell renal cell carcinoma. Through multi-omic analysis of multiregion tumor biopsies taken pre- and post-treatment, Au et al. evaluate genomic and tumor immune microenvironment features underpinning anti-PD-1 response and resistance using bulk and single-cell approaches.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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