•The article discusses pocket parks towards more sustainable and resilient cities.•Illustrates features and benefits of pocket parks with a multi-disciplinary perspective.•Explores the challenges for their implementation in Mediterranean urban areas.•Proposes an integrated framework to favor pocket parks’ creation and management.•Presents multi-disciplinary best practices that can favor PP's diffusion. Pocket-sized urban parks may contribute to more widely distributing the advantages created by parks in urban neighborhoods, allowing more citizens to benefit more frequently from park environments. Notwithstanding their several benefits, including citizens’ psychological, physiological and physical well-being; possibilities for recreational activities; and improved economic attractiveness of a neighborhood, pocket parks (PPs) are not yet widely diffused worldwide. Considering the state of the art of PPs, we identify four main perspectives that characterize them: architectural, microclimate, managerial and legal. Focusing on a relevant case study, i.e., the Mediterranean context, we analyze the multi-disciplinary challenges – connected to the four identified dimensions – for their diffusion elsewhere. Finally, we provide a general framework for favoring PPs’ creation and management, as the original contribution of this work. Besides advancing scientific knowledge about PPs, our results also interest policymakers and public organizations, as the diffusion of PPs can mitigate urban environmental challenges by creating pleasant experiences for citizens and favoring economic activities.