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Matlahov, Irina; van der Wel, Patrick C.A.
Methods (San Diego, Calif.), 09/2018, Letnik: 148Journal Article
•Solid-state NMR methods measure structure and dynamics in biological assemblies.•Dynamics affect NMR-detected resonances, interactions and relaxation properties.•Dynamics-based spectral editing isolates signals based on their relative dynamics.•Dynamic filtering enables simplification of complex spectra of large biomolecules.•Co-existing rigid and mobile molecules and domains are unambiguously distinguished. Solid-state nuclear magnetic resonance (ssNMR) spectroscopy enables the structural characterization of a diverse array of biological assemblies that include amyloid fibrils, non-amyloid aggregates, membrane-associated proteins and viral capsids. Such biological samples feature functionally relevant molecular dynamics, which often affect different parts of the sample in different ways. Solid-state NMR experiments’ sensitivity to dynamics represents a double-edged sword. On the one hand, it offers a chance to measure dynamics in great detail. On the other hand, certain types of motion lead to signal loss and experimental inefficiencies that at first glance interfere with the application of ssNMR to overly dynamic proteins. Dynamics-based spectral editing (DYSE) ssNMR methods leverage motion-dependent signal losses to simplify spectra and enable the study of sub-structures with particular motional properties.
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