Drug induced liver injury (DILI) is an adverse drug reaction that causes liver damage in a predictable (dose-dependent) or an unpredictable (idiosyncratic) fashion. We performed an assessment of DILI in Portugal, by analyzing the reports, sent to the Portuguese Pharmacovigilance System (PPS). A search was performed on the PPS database, in a 10-year time frame, from 1 January 2010 to 31 December 2019. There was not a prevalence of either sex in any age group. Most reports ( = 1120, 55.0%) belonged to patients in the age group 19-64 years old. Hepatitis ( = 626, 26.7%) was the most common adverse drug reaction in our study. Hepatotoxicity ( = 362, 15.5%) and hepatitis ( = 333, 14.2%) were more frequent in age group 19-64 years old. Cholestasis was more prevalent in adults independently of age. Hepatic fibrosis and encephalopathy were more common in the elderly. Most patients consumed between one and four suspected drugs ( = 1867, 92%). Most patients in our study evolved to "cure" ( = 796; 39%). Hepatotoxicity ( = 23; 13.8%) and hepatitis ( = 610; 25.9%) had a female predominancy while choluria ( = 8; 4.8%) and splenomegaly ( = 8; 4.8%) were of male predominance. DILI is rare but can be fatal. As such, an active search of DILI is necessary.