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Bardwell, Philip D.; Staron, Matthew M.; Liu, Junjian; Tao, Qingfeng; Scesney, Susanne; Bukofzer, Gail; Rodriguez, Luis E.; Choi, Chee-Ho; Wang, Jennifer; Chang, Qing; Dong, Feng; Donawho, Cherrie; Wang, Jieyi; Grinnell, Christine M.; Tarcsa, Edit; Hutchins, Charles; Ghayur, Tariq; Gu, Jijie
Protein & Cell, 01/2018, Letnik: 9, Številka: 1Journal Article
Novel biologics that redirect cytotoxic T lymphocytes (CTLs) to kill tumor cells bearing a tumor associated antigen hold great promise in the clinic. However, the ability to safely and potently target CD3 on CTL toward tumor associated antigens (TAA) expressed on tumor cells remains a challenge of both technology and biology. Herein we describe the use of a Half DVD-Ig format that can redirect CTL to kill tumor cells. Notably, Half DVD-Ig molecules that are monovalent for each specificity demonstrated reduced non-specific CTL activation and conditional CTL activation upon binding to TAA compared to intact tetravalent DVD-Ig molecules that are bivalent for each specificity, while maintaining good drug like properties and appropriate PK properties.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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