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Guidotti, Luca G; Isogawa, Masanori; Chisari, Francis V
Current opinion in immunology, 10/2015, Letnik: 36Journal Article
Highlights • Hepatocellular HBV infection is noncytopathic. • HBV does not induce a measurable innate immune response in vivo. • Robust, broad adaptive immune responses mediate HBV clearance and acute hepatitis. • Weak, narrow adaptive responses mediate HBV persistence and chronic hepatitis. • Chronic hepatitis evolves to cirrhosis of the liver and hepatocellular carcinoma.
