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Benet, Zachary L; Marthi, Matangi; Ke, Fang; Wu, Rita; Turner, Jackson S; Gabayre, Jahan B; Ivanitskiy, Michael I; Sethi, Sahil S; Grigorova, Irina L
Frontiers in immunology, 09/2018, Letnik: 9Journal Article
Previous studies and our findings suggest upregulated expression of proinflammatory chemokines CCL3/4 in germinal center (GC) centrocytes. However, the role of CCL3/4 for centrocyte interactions with follicular T cells and regulation of humoral immunity is poorly understood. We found that CCL3 promotes chemotaxis of Tfr cells . Two-photon imaging revealed that B cells-intrinsic production of CCL3 promotes their probing by follicular regulatory T cells (Tfr) within GCs of murine lymph nodes. Overall this study suggests that CCL3 facilitates direct interactions of foreign antigen-specific GC B cells and their negative regulation with Tfr cells .
