E-viri
Recenzirano
Odprti dostop
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Nieto, Maria Asuncion; Sanchez-Pernaute, Olga; Vadillo, Cristina; Rodriguez-Nieto, Maria Jesus; Romero-Bueno, Fredeswinda; López-Muñiz, Belen; Cebrian, Laura; Rio-Ramirez, Maria Teresa; Laporta, Rosalia; Bonilla, Gema; Cobo, Tatiana; Leon, Leticia; Abasolo, Lydia
Respiratory research, 01/2023, Letnik: 24, Številka: 1Journal Article
The objective of the present study is to describe the characteristics of interstitial pneumonia with autoimmune features (IPAF) patients, to assess the incidence rate of functional respiratory impairment over time and to evaluate the influence of therapeutic alternatives on the prognosis of these patients. A longitudinal observational multicenter study was performed (NEREA registry). It was carried out by a multidisciplinary team in seven Hospitals of Madrid. Patients were included from IPAF diagnosis. poor prognosis as functional respiratory impairment (relative decline in FVC % defined as ≥ 5% every 6 months). Covariates: therapy, sociodemographic, clinical, radiological patterns, laboratory and functional tests. Survival techniques were used to estimate IR per 100 patients-semester with their 95% confidence interval CI. The influence of covariates in prognosis were analyzed through cox multivariate regression models (hazard ratio (HR) and CI). 79 IPAF were included, with a mean and a maximum follow-up of 3.17 and 12 years respectively. Along the study, 77.2% received treatment (52 glucocorticoids, 25 mycophenolate, 21 azathioprine, 15 rituximab and 11 antifibrotics). IR was 23.9 19.9-28.8, and 50% of IPAF developed functional respiratory impairment after 16 months from its diagnosis. Multivariate analysis: usual interstitial pneumonia (UIP) had poorer prognosis compared to non-specific interstitial pneumonia (NSIP) (p = 0.001). In NSIP, positive ANA, increased the risk of poor prognosis. In UIP, glucocorticoids (HR: 0.53 0.34-0.83), age (HR: 1.04 1.01-1.07), and Ro-antibodies (HR: 0.36 0.19-0.65) influenced the prognosis. IPAF have functional impairment during the first years of disease. Factors predicting deterioration differ between radiographic patterns. Our real-life study suggests the potential benefit of particular therapies in IPAF.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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