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Posner, Holly B; Cano, Stefan; Carrillo, Maria C; Selnes, Ola; Stern, Yaakov; Thomas, Ronald G; Zajicek, John; Hobart, Jeremy
Alzheimer's & dementia, February 2013, Letnik: 9, Številka: 1Journal Article
Abstract The Alzheimer's disease (AD) Cognitive Behavior Section (ADAS-Cog) is the most commonly used cognitive test in clinical trials of AD. Recent trials have focused on people earlier in the course of disease; however, there are concerns about using the ADAS-Cog at this crucial stage. Using data from the Alzheimer's disease Neuroimaging Initiative study, we used a range of traditional psychometric tests to evaluate those concerns. This issue of Alzheimer's & Dementia includes two articles that evaluate the ADAS-Cog. These articles report evaluations using two psychometric approaches: traditional methods and new methods. In this review, we provide accompanying background information to this program of research.
