E-viri
Recenzirano
Odprti dostop
-
Strunz, Maximilian; Simon, Lukas M; Ansari, Meshal; Kathiriya, Jaymin J; Angelidis, Ilias; Mayr, Christoph H; Tsidiridis, George; Lange, Marius; Mattner, Laura F; Yee, Min; Ogar, Paulina; Sengupta, Arunima; Kukhtevich, Igor; Schneider, Robert; Zhao, Zhongming; Voss, Carola; Stoeger, Tobias; Neumann, Jens H L; Hilgendorff, Anne; Behr, Jürgen; O'Reilly, Michael; Lehmann, Mareike; Burgstaller, Gerald; Königshoff, Melanie; Chapman, Harold A; Theis, Fabian J; Schiller, Herbert B
Nature communications, 07/2020, Letnik: 11, Številka: 1Journal Article
The cell type specific sequences of transcriptional programs during lung regeneration have remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model, we resolved transcriptional dynamics for 28 cell types. Trajectory modeling together with lineage tracing revealed that airway and alveolar stem cells converge on a unique Krt8 + transitional stem cell state during alveolar regeneration. These cells have squamous morphology, feature p53 and NFkB activation and display transcriptional features of cellular senescence. The Krt8+ state appears in several independent models of lung injury and persists in human lung fibrosis, creating a distinct cell-cell communication network with mesenchyme and macrophages during repair. We generated a model of gene regulatory programs leading to Krt8+ transitional cells and their terminal differentiation to alveolar type-1 cells. We propose that in lung fibrosis, perturbed molecular checkpoints on the way to terminal differentiation can cause aberrant persistence of regenerative intermediate stem cell states.
Avtor
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.