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Lu, Lu; Chen, Lin-Lei; Zhang, Ricky Rui-Qi; Tsang, Owen Tak-Yin; Chan, Jacky Man-Chun; Tam, Anthony Raymond; Leung, Wai-Shing; Chik, Thomas Shiu-Hong; Lau, Daphne Pui-Ling; Choi, Chris Yau-Chung; Fong, Carol Ho-Yan; Cai, Jian-Piao; Tsoi, Hoi-Wah; Choi, Charlotte Yee-Ki; Zhang, Xiaojuan; Abdullah, Syed Muhammad Umer; Chan, Brian Pui-Chun; Chan, Kwok-Hung; Yuen, Kwok-Yung; Hung, Ivan Fan-Ngai; To, Kelvin Kai-Wang
EBioMedicine, 05/2022, Letnik: 79Journal Article
SARS-CoV-2 Omicron variant evades immunity from past infection or vaccination and is associated with a greater risk of reinfection among recovered COVID-19 patients. We assessed the serum neutralizing antibody (NAb) activity against Omicron variant (Omicron NAb) among recovered COVID-19 patients with or without vaccination. In this prospective cohort study with 135 recovered COVID-19 patients, we determined the serum NAb titers against ancestral virus or variants using a live virus NAb assay. We used the receiver operating characteristic analysis to determine the optimal cutoff for a commercially-available surrogate NAb assay. Among recovered COVID-19 patients, the serum live virus geometric mean Omicron NAb titer was statistically significantly higher among BNT162b2 recipients compared to non-vaccinated individuals (85.4 vs 5.6,P < 0.0001). The Omicron seropositive rates in live virus NAb test (NAb titer ≥10) were statistically significantly higher among BNT162b2 (90.6% 29/32;P < 0.0001) or CoronaVac (36.7% 11/30; P = 0.0115) recipients when compared with non-vaccinated individuals (12.3% 9/73). Subgroup analysis of CoronaVac recipients showed that the Omicron seropositive rates were higher among individuals with two doses than those with one dose (85.7% vs 21.7%; P = 0.0045). For the surrogate NAb assay, a cutoff of 109.1 AU/ml, which is 7.3-fold higher than the manufacturer's recommended cutoff, could achieve a sensitivity and specificity of 89.5% and 89.8%, respectively, in detecting Omicron NAb. Among individuals with prior COVID-19, one dose of BNT162b2 or two doses of CoronaVac could induce detectable serum Omicron NAb. Our result would be particularly important for guiding vaccine policies in countries with COVID-19 vaccine shortage. Health and Medical Research Fund, Richard and Carol Yu, Michael Tong (see acknowledgments for full list).
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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