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Armstrong, Casey C; Moody, Teena D; Feusner, Jamie D; McCracken, James T; Chang, Susanna; Levitt, Jennifer G; Piacentini, John C; O’Neill, Joseph
Journal of affective disorders, 03/2016, Letnik: 193Journal Article
Abstract Background fMRI graph theory reveals resting-state brain networks, but has never been used in pediatric OCD. Methods Whole-brain resting-state fMRI was acquired at 3 T from 21 children with OCD and 20 age-matched healthy controls. BOLD connectivity was analyzed yielding global and local graph-theory metrics across 100 child-based functional nodes. We also compared local metrics between groups in frontopolar, supplementary motor, and sensorimotor cortices, regions implicated in recent neuroimaging and/or brain stimulation treatment studies in OCD. Results As in adults, the global metric small-worldness was significantly ( P <0.05) lower in patients than controls, by 13.5% (%mean difference=100%X(OCD mean – control mean)/control mean). This suggests less efficient information transfer in patients. In addition, modularity was lower in OCD (15.1%, P <0.01), suggesting less granular – or differently organized – functional brain parcellation. Higher clustering coefficients (23.9–32.4%, P <0.05) were observed in patients in frontopolar, supplementary motor, sensorimotor, and cortices with lower betweenness centrality (−63.6%, P <0.01) at one frontopolar site. These findings are consistent with more locally intensive connectivity or less interaction with other brain regions at these sites. Limitations Relatively large node size; relatively small sample size, comorbidities in some patients. Conclusions Pediatric OCD patients demonstrate aberrant global and local resting-state network connectivity topologies compared to healthy children. Local results accord with recent views of OCD as a disorder with sensorimotor component.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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