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Thress, Kenneth S; Brant, Roz; Carr, T. Hedley; Dearden, Simon; Jenkins, Suzanne; Brown, Helen; Hammett, Tracey; Cantarini, Mireille; Barrett, J. Carl
Lung cancer (Amsterdam, Netherlands), 12/2015, Letnik: 90, Številka: 3Journal Article
Highlights • Multiple platforms were compared for detection of EGFR mutations in plasma ctDNA. • Digital and traditional PCR assays were assessed using plasma from AZD9291 trials. • Multiple platforms enabled robust detection of common EGFR-sensitizing mutations. • cobas® and BEAMing assays showed >70% sensitivity for plasma T790M detection. • Genomic heterogeneity of T790M may explain most plasma-tissue discordance.
