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Vokali, Efthymia; Yu, Shann S; Hirosue, Sachiko; Rinçon-Restrepo, Marcela; V Duraes, Fernanda; Scherer, Stefanie; Corthésy-Henrioud, Patricia; Kilarski, Witold W; Mondino, Anna; Zehn, Dietmar; Hugues, Stéphanie; Swartz, Melody A
Nature communications, 01/2020, Letnik: 11, Številka: 1Journal Article
Lymphatic endothelial cells (LECs) chemoattract naïve T cells and promote their survival in the lymph nodes, and can cross-present antigens to naïve CD8 T cells to drive their proliferation despite lacking key costimulatory molecules. However, the functional consequence of LEC priming of CD8 T cells is unknown. Here, we show that while many proliferating LEC-educated T cells enter early apoptosis, the remainders comprise a long-lived memory subset, with transcriptional, metabolic, and phenotypic features of central memory and stem cell-like memory T cells. In vivo, these memory cells preferentially home to lymph nodes and display rapid proliferation and effector differentiation following memory recall, and can protect mice against a subsequent bacterial infection. These findings introduce a new immunomodulatory role for LECs in directly generating a memory-like subset of quiescent yet antigen-experienced CD8 T cells that are long-lived and can rapidly differentiate into effector cells upon inflammatory antigenic challenge.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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