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Agboyibor, Clement; Dong, Jianshu; Effah, Clement Yaw; Drokow, Emmanuel Kwateng; Ampomah-Wireko, Maxwell; Pervaiz, Waqar; Sangmor, Augustina; Ma, Xinli; Li, Jian; Liu, Hong-Min; Zhang, Peng
Biomedicine & pharmacotherapy, January 2023, 2023-Jan, 2023-01-00, 20230101, 2023-01-01, Letnik: 157Journal Article
It has been proven that metastatic recurrence and therapeutic resistance are linked. Due to the variability of individuals and tumors, as well as the tumor's versatility in avoiding therapies, therapy resistance is more difficult to treat. Therapy resistance has significantly restricted the clinical feasibility and efficacy of tumor therapy, despite the discovery of novel compounds and therapy combinations with increasing efficacy. In several tumors, lysine specific demethylase 1 (LSD1) has been associated to metastatic recurrence and therapeutic resistance. For researchers to better comprehend how LSD1-mediated tumor therapy resistance occurs and how to overcome it in various tumors, this study focused on the role of LSD1 in tumor recurrence and therapeutic resistance. The importance of therapeutically targeted LSD1 was also discussed. Most gene pathway signatures are related to LSD1 inhibitor sensitivity. However, some gene pathway signatures, especially in AML, negatively correlate with LSD1 inhibitor sensitivity, but targeting LSD1 makes the therapy-resistant tumor sensitive to physiological doses of conventional therapy. We propose that combining LSD1 inhibitor with traditional tumor therapy can help patients attain a complete response and prevent cancer relapse. •Drug resistance has severely restricted the clinical feasibility and efficiency of tumor therapy treatment.•LSD1 has been linked to therapy resistance, and most gene pathway signatures are related to LSD1 inhibitor sensitivity.•Some gene pathway signatures, especially in AML, have a negative correlation with LSD1 inhibitor sensitivity.•LSD1 deletion makes the therapy resistant tumor sensitive to physiological doses of conventional therapy.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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