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Munusamy Ponnan, Sivasankaran; Hayes, Peter; Fernandez, Natalia; Thiruvengadam, Kannan; Pattabiram, Sathyamurthi; Nesakumar, Manohar; Srinivasan, Ashokkumar; Kathirvel, Sujitha; Shankar, Janani; Goyal, Rajat; Singla, Nikhil; Mukherjee, Joyeeta; Chatrath, Shweta; Gilmour, Jill; Subramanyam, Sudha; Prasad Tripathy, Srikanth; Swaminathan, Soumya; Hanna, Luke Elizabeth
PloS one, 2020, Letnik: 15, Številka: 2Journal Article
T cells play an important role in controlling viral replication during HIV infection. An effective vaccine should, therefore, lead to the induction of a strong and early viral-specific CD8+ T cell response. While polyfunctional T cell responses are thought to be important contributors to the antiviral response, there is evidence to show that polyfunctional HIV- specific CD8+ T cells are just a small fraction of the total HIV-specific CD8+ T cells and may be absent in many individuals who control HIV replication, suggesting that other HIV-1 specific CD8+ effector T cell subsets may be key players in HIV control. Stem cell-like memory T cells (TSCM) are a subset of T cells with a long half-life and self-renewal capacity. They serve as key reservoirs for HIV and contribute a significant barrier to HIV eradication. The present study evaluated vaccine-induced antiviral responses and TSCM cells in volunteers vaccinated with a subtype C prophylactic HIV-1 vaccine candidate administered in a prime-boost regimen. We found that ADVAX DNA prime followed by MVA boost induced significantly more peripheral CD8+ TSCM cells and higher levels of CD8+ T cell-mediated inhibition of replication of different HIV-1 clades as compared to MVA alone and placebo. These findings are novel and provide encouraging evidence to demonstrate the induction of TSCM and cytotoxic immune responses by a subtype C HIV-1 prophylactic vaccine administered using a prime-boost strategy.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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