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Karelou, Maria; Kampasis, Dionysis; Kalampaliki, Amalia D; Persoons, Leentje; Krämer, Andreas; Schols, Dominique; Knapp, Stefan; De Jonghe, Steven; Kostakis, Ioannis K
Molecules (Basel, Switzerland), 12/2023, Letnik: 28, Številka: 23Journal Article
Sixteen new 2-substituted quinazolines were synthesized using a straightforward methodology starting from 2-methoxybezoic acid or 3-methoxy-2-naphthoic acid. The anti-proliferative activity of the target compounds was evaluated against nine cancer cell lines. Additionally, all the compounds were screened for their potency and selectivity against a panel of 109 kinases and four bromodomains, using Differential Scanning Fluorimetry (DSF). Compound bearing a 2-methoxyphenyl substitution along with a basic side chain displayed a remarkable profile against the majority of the tested cell lines.
