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Monterrubio, Carles; Paco, Sonia; Olaciregui, Nagore G.; Pascual-Pasto, Guillem; Vila-Ubach, Monica; Cuadrado-Vilanova, Maria; Ferrandiz, M. Mar; Castillo-Ecija, Helena; Glisoni, Romina; Kuplennik, Nataliya; Jungbluth, Achim; de Torres, Carmen; Lavarino, Cinzia; Cheung, N.K.V.; Mora, Jaume; Sosnik, Alejandro; Carcaboso, Angel M.
Journal of controlled release, 06/2017, Letnik: 255Journal Article
Neuroblastoma is a pediatric solid tumor with high expression of the tumor associated antigen disialoganglioside GD2. Despite initial response to induction therapy, nearly 50% of high-risk neuroblastomas recur because of chemoresistance. Here we encapsulated the topoisomerase-I inhibitor SN-38 in polymeric nanoparticles (NPs) surface-decorated with the anti-GD2 mouse mAb 3F8 at a mean density of seven antibody molecules per NP. The accumulation of drug-loaded NPs targeted with 3F8 versus with control antibody was monitored by microdialysis in patient-derived GD2-expressing neuroblastoma xenografts. We showed that the extent of tumor penetration by SN-38 was significantly higher in mice receiving the targeted nano-drug delivery system when compared to non-targeted system or free drug. This selective penetration of the tumor extracellular fluid translated into a strong anti-tumor effect prolonging survival of mice bearing GD2-high neuroblastomas in vivo. Display omitted
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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