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Crisostomo, Fernando Pinacho; Martin, Tomás; Carrillo, Romen
Angewandte Chemie International Edition, 02/2014, Letnik: 53, Številka: 8Journal Article
Ascorbic acid (vitaminC) has been used as a radical initiator in a metal-free direct CH arylation of (hetero)arenes. Starting from an aniline, the corresponding arenediazonium ion is generated in situ and immediately reduced by vitaminC to an aryl radical that undergoes a homolytic aromatic substitution with a (hetero)arene. Notably, neither heating nor irradiation is required. This procedure is mild, operationally simple, and constitutes a greener approach to arylation. PUBLICATION ABSTRACT
