BACKGROUND :The study of breast cancer has evolved from histopathological examination alone to the present scenario when further ancillary techniques including IHC, FISH and Genetic studies have been incorporated. Scrape cytology provides excellent cellular details and has the added advantage of being inexpensive, simple and quick. IHC helps the treating oncologist to predict the response to standard modalities of treatment and also aids in prognosticating the disease process.OBJECTIVES1) To perform scrape cytology on fresh unfixed specimen of suspected carcinoma breast received in the Department of Pathology during the period of study.2) To correlate the cytological and histopathological diagnosis.3) To study the expression of estrogen and progesterone receptors in carcinoma breast cases.MATERIALS AND METHODS :50 patients of suspected carcinoma breast who underwent surgery in K V G Medical College and Hospital, Sullia, D.K from November 2015 to August 2017 were included in the study. The specimens were cytologically examined by scrape method. Later on histopathological examination was done followed by ER, PR estimation.RESULTS :Sensitivity of scrape cytology in providing a specific diagnosis was 96% with a positive predictive value of 100%. In our study, 24 (48%) expressed estrogen receptors and 23 (64%) expressed progesterone receptors. Majority of the patients, 25 (50%) belonged to ER/PR negative group. Histological grading using the Modified Bloom-Richardson system showed a significant association with the receptor expression.CONCLUSION :Scrape cytology is a diagnostically reliable modality according to our study. Therefore, it is suggested to be a part of pathologist’s repertoire though in the present times it is not the usual practice. ER and PR status correlates well with histopathological grading and other clinico-pathological parameters. This will guide the clinicians to make correct choice of treatment protocols and helps in improved quality of life.