The Fourth Industrial Revolution creates increasing demands for workers with new skill sets. Since studies on career adaptability and its antecedents among workers have received less research attention, we examined the level of career adaptability and factors on career adaptability in the Fourth Industrial Revolution. Data were collected from 612 workers in Binh Duong province in Vietnam. Findings showed that workers in Binh Duong province were highly adapted to the impact of the Fourth Industrial Revolution. Findings also indicated that a collective significant effect was found in low socioeconomic status, unhealthiest, low skill and no vocational training, and difficulty in establishing relationships with colleagues and managers. In contrast, a collective significant effect was not found in low awareness of work changes due to the Forth Industrial Revolution, low qualification and experience, and old ages. We have discussed the implications and limitations of our findings.