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Isaka, Masahiko; Palasarn, Somporn; Supothina, Sumalee; Srichomthong, Kitlada; Choeyklin, Rattaket
Helvetica chimica acta, 03/2016, Letnik: 99, Številka: 3Journal Article
A new seco-tremulane, 11,12-epoxy-5,6-secotremula-1,6(13)-dien-5,12-olide (1), was isolated together with the known compounds, conocenolides A (2) and B (3), tremulenediol A (4), tremulenolide A (5), and two lanostane triterpenoids, trametenolic acid B (6), and pinicolic acid A (7), from cultures of the basidiomycete Flavodon flavusBCC 17421. Interconversion of conocenolides A/B was demonstrated. Compound 1 exhibited weak cytotoxic activities, whereas tremulenediol A showed antiplasmodial activity (IC50 8.6 µg/ml). Pinicolic acid A exhibited activity against herpes simplex virus type-1 (IC50 15 µg/ml) as well as cytotoxic activities.
