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Manfredi, R; Motta, R; Patrono, D; Calza, L; Chiodo, F; Boni, P
AIDS (London), 09/2003, Letnik: 17, Številka: 14Journal Article
Among 743 HIV-infected patients, a 6-month case-control study disclosed a 35.9% rate of hyperlactatemia in those with a longer duration of anti-HIV therapy, lipodystrophy, and elevated triglyceride, creatine phosphokinase, and aldolase levels. The 52 patients with sustained lactacidemia and the five with grade 4 hyperlactatemia showed no different supporting factors and courses compared with those with isolated or low-level abnormalities. No relationship emerged with nucleoside analogue use. Hyperlactatemia, although frequently transient and asymptomatic, warrants careful attention.
