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Klimecka, Agnieszka; Kupczewska-Dobecka, Małgorzata; Konieczko, Katarzyna; Jurewicz, Joanna
Medycyna pracy, 11/2023, Letnik: 74, Številka: 6Journal Article
The inhalation exposure assessment is regulated by law, while in Poland the method of conducting measurements for dermal exposure has not been indicated in the law. ...due to the restrictions 71 and 76 from Annex XVII of REACH for 1-methyl-2-pyrrolidone (NMP) and N,N-dimethylformamide (DMF), exposure assessment by the dermal route is necessary. The ECETOC TRA was considered the best model for this type of analysis, whose main advantages are direct comparison of the output data in mg/kg/day with the DNEL value and use of standardized descriptors system. Conclusions: Exposure modeling is a good and cheap way to determine the dermal exposure magnitude at workplaces, also to comply with the requirements of restrictions 71 and 76 of Annex XVII of REACH.
