E-viri
Recenzirano
Odprti dostop
-
Mahajan, Anubha; Go, Min Jin; Gaulton, Kyle J; Prokopenko, Inga; Wang, Xu; Abecasis, Goncalo R; Balkau, Beverley; Barnett, Anthony H; Beilby, John; Bell, Graeme I; Burtt, Noël; Chang, Li-Ching; Chen, Han; Chidambaram, Manickam; Chines, Peter S; Cho, Nam H; Cho, Young Min; van Dam, Rob M; Danesh, John; Dedoussis, George; Doney, Alex S; Donnelly, Peter J; Emilsson, Valur; Eriksson, Johan G; Florez, Jose C; Forsen, Tom; Fox, Caroline; Fraser, Ross M; Gigante, Bruna; Grant, George B; Grundberg, Elin; Hamsten, Anders; Hara, Kazuo; Hattersley, Andrew T; Herder, Christian; Hveem, Kristian; Hydrie, Zafar I; Ingelsson, Erik; Islam, Muhammed; Jackson, Anne U; Jafar, Tazeen; Kadowaki, Takashi; Kang, Hyun Min; Kao, Wen Hong L; Kato, Norihiro; Kelly, Ann M; Kim, Sangsoo; Kong, Augustine; Kraft, Peter; Kravic, Jasmina; Kumar, Ashish; Kuusisto, Johanna; Lagou, Vasiliki; Langenberg, Claudia; Lee, Jen-Mai; Li, Yun; Lindholm, Eero; Loos, Ruth J F; Maeda, Shiro; Mägi, Reedik; Männisto, Satu; Matthews, David R; Morris, Andrew D; Navarro, Pau; Pankow, James S; Park, Kyong Soo; Platou, Carl G; Qi, Lu; Rauramaa, Rainer; Raychaudhuri, Soumya; Rybin, Denis; Saaristo, Timo E; Saltevo, Juha; Segrè, Ayellet V; Sennblad, Bengt; Sigurđsson, Gunnar; Stefansson, Kari; Steinthorsdottir, Valgerdur; Stirrups, Kathleen; Stringham, Heather M; Suo, Chen; Thorleifsson, Gudmar; Tremoli, Elena; Tsai, Fuu Jen; Tuomilehto, Jaakko; Veglia, Fabrizio; Wareham, Nicholas J; Wilsgaard, Tom; Wilson, James F; Wong, Tien Yin; Wu, Ying; Yamamoto, Ken; Zhang, Fan; Zheng, Wei; Bowden, Donald W; Cox, Nancy J; Cruz, Miguel; Seielstad, Mark; Parra, Esteban J; Morris, Andrew P
Nature genetics, 03/2014, Letnik: 46, Številka: 3Journal Article
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry.
Avtor
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.