The effects of pressure on flow boiling instabilities in microchannels were experimentally studied. Experiments were conducted using water in 223 μm hydraulic diameter microchannels with mass fluxes ranging from 86 to 520 kg/m 2 s and pressures ranging from 50 to 205 kPa. Onset of flow oscillation, critical heat flux (CHF) conditions, local transient temperature measurements along with flow boiling visualization were obtained and studied. System pressure was found to significantly affect flow instabilities. For high pressure, it was observed that boiling instabilities were significantly delayed and CHF was extended to high mass qualities. Local temperature measurements also revealed lower magnitudes and higher frequencies of oscillations at high system pressures.