Purpose: To analyse if there are retina microvascular changes and choroidal thickness changes correlate with the degree of disability among patients with sclerosis multiple (MS) disease during a year. Methods: It was analysed the vascular changes (choroidal thickness and vascular macular plexuses) using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) in multiple sclerosis (MS) according to the degree of disability measured by the expanded disability status scale (EDSS) in 1 year prospective study. Patients were divided into two groups: low disability group (EDSS score ≤ 3) and high disability group (EDSS > 3). Anatomical parameters and duration of the course disease was also analysed. Any subject has neuritis history and patients were divided depend on the type of MS: relapsing–remitting multiple sclerosis (RRMS) and primary progressive multiple sclerosis (PPMS). Results: Anatomical parameters were thinner in patients with the highest degree of disability and in patients with PPMS. Macular choroidal thickness (MCT) showed a significant decrease in the group which had moderate–severe disability. Retinal vascular macular plexuses showed no difference according to the EDSS score or type of MS. Conclusions: Patients with a clinical worsening of their MS at 1 year showed a significant decrease in macular choroidal thickness compared to their baseline situation.