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Montal, Victor; Vilaplana, Eduard; Alcolea, Daniel; Pegueroles, Jordi; Pasternak, Ofer; González-Ortiz, Sofia; Clarimón, Jordi; Carmona-Iragui, María; Illán-Gala, Ignacio; Morenas-Rodríguez, Estrella; Ribosa-Nogué, Roser; Sala, Isabel; Sánchez-Saudinós, María-Belén; García-Sebastian, Maite; Villanúa, Jorge; Izagirre, Andrea; Estanga, Ainara; Ecay-Torres, Mirian; Iriondo, Ane; Clerigue, Montserrat; Tainta, Mikel; Pozueta, Ana; González, Andrea; Martínez-Heras, Eloy; Llufriu, Sara; Blesa, Rafael; Sanchez-Juan, Pascual; Martínez-Lage, Pablo; Lleó, Alberto; Fortea, Juan
Alzheimer's & dementia, March 2018, Letnik: 14, Številka: 3Journal Article
Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD). We included healthy control subjects (N = 254), mild cognitive impairment (N = 41), and AD dementia (N = 31) patients. Participants underwent a lumbar puncture and a 3 T magnetic resonance imaging. Healthy control subjects were classified following National Institute on Aging-Alzheimer's Association stages (stage 0, N = 220; stage 1, N = 25; and stage 2/3, N = 9). We assessed the cortical MD, cortical FW, and cortical thickness (CTh) changes along the AD continuum. Microstructural and macrostructural changes show a biphasic trajectory. Stage 1 subjects showed increased CTh and decreased MD and FW with respect the stage 0 subjects. Stage 2/3 subjects showed decreased CTh and increased cortical MD and FW, changes that were more widespread in symptomatic stages. These results support a biphasic model of changes in AD, which could affect the selection of patients for clinical trials and the use of magnetic resonance imaging as a surrogate marker of disease modification.
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