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St-Pierre, Julie; Tremblay, Michel L.
Cell metabolism, 03/2012, Letnik: 15, Številka: 3Journal Article
Leptin plays a central role in weight control by suppressing food intake and increasing energy expenditure. The concept of leptin resistance emerged to explain the seemingly paradoxical elevated leptin levels in obesity. Recent discoveries reveal that protein tyrosine phosphatases are key players in leptin resistance by globally suppressing leptin signaling.
