This paper presents isogeometric topology optimization (ITO) for periodic lattice materials, where non-uniform rational B-spline (NURBS) basis functions of CAD models are directly used in the finite element analysis to improve computational accuracy and efficiency. Two TO schemes that use asymptotic homogenization (AH) for the calculation of the mechanical properties are proposed for lattice materials with uniform and graded relative density respectively. To accelerate ITO for graded lattice materials, the mechanical properties are expressed as a function of the relative density of the unit cell, a step that avoids their iterative calculations during ITO. Three benchmark examples are presented to validate the proposed scheme with results that show tangible advantages, such as reduced computational time and faster convergence, of ITO over conventional TO. •A multiscale isogeometric topology optimization is presented for lattice materials.•Asymptotic homogenization is coupled to topology optimization for lattice design.•The role of cell topology is demonstrated in the optimal density distribution of lattices.•Benchmark examples are presented to prove the efficiency of the proposed scheme.