We present some open questions in nucleosynthesis focused on the measurement of relevant neutron capture cross-sections and on new experimental methods. We review the recent super(63)Ni(n, gamma ) experiment carried out at the n_TOF facility at CERN and its astrophysical implications as well as future experiments and opportunities at n_TOF. We argue some improvements in the measurement of cross-sections by activation arising from a new method for the generation of stellar neutron spectra. We show preliminary results of the experimental validation of the method. We discuss the astrophysical implications of the super(181)Ta(n, gamma ) stellar cross-section measured with this method. Finally, we describe challenging experiments consisting of in situ radioactive ion beams and stellar neutron beams.