The nearby super-Earth 55 Cnc e orbits a bright (V = 5.95 mag) star with a period of ∼18 hr and a mass of ∼8M⊕. Its atmosphere may be water-rich and have a large-scale height; though, attempts to characterize it have yielded ambiguous results. Here we present a sensitive search for water and TiO in its atmosphere at high spectral resolution using the Gemini North telescope and the GRACES spectrograph. We combine observations with previous observations from Subaru and CFHT, improving the constraints on the presence of water vapor. We adopt parametric models with an updated planet radius based on recent measurements, and use a cross-correlation technique to maximize sensitivity. Our results are consistent with atmospheres that are cloudy or contain minimal amounts of water and TiO. Using these parametric models, we rule out a water-rich atmosphere (VMR 0.1%) with a mean molecular weight of 15 g mol−1 at a 3 confidence level, improving on the previous limit by a significant margin. For TiO, we rule out a mean molecular weight of 5 g mol−1 with a 3 confidence level for a VMR greater than 10−8; for a VMR of greater than 10−7, the limit rises to a mean molecular weight of 10 g mol−1. We can rule out low mean-molecular-weight chemical equilibrium models both including and excluding TiO/VO at very high confidence levels (>10 ). Overall, our results are consistent with an atmosphere with a high mean molecular weight and/or clouds, or no atmosphere.