Integrated bipolar Operational Amplifier (op-amp) type μA 741 was irradiated with neutrons and gamma rays. The radiation on gain factors, slew rate, and power supply current have been evaluated. The experimental results show a decrease of these parameter values after exposing to the radiation. The advantage of the increase of the voltage power supplies and the thermal annealing treatment on the damaged parameters was also explored. The relationship among different frequency response parameters is also studied leading to an analytical formula for the above degraded parameters. •The radiation effects on frequency parameters of 741 op-amp have been studied.•The irradiation was achieved using gamma rays and neutrons.•The irradiation degrades the op-amp parameters.•This degradation is referred to the that of the current gain transistors hFE.•Thermal annealing restores the degraded parameters.