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Buschmann, E. E.; Utz, W.; Pagonas, N.; Schulz-Menger, J.; Busjahn, A.; Monti, J.; Maerz, W.; Le Noble, F.; Thierfelder, L.; Dietz, R.; Klauss, V.; Gross, M.; Buschmann, I.R.
European journal of clinical investigation, October 2009, Letnik: 39, Številka: 10Journal Article
Background Arteriogenesis (collateral artery growth) is nature’s most efficient rescue mechanism to overcome the fatal consequences of arterial occlusion or stenosis. The goal of this trial was to investigate the effect of external counterpulsation (ECP) on coronary collateral artery growth. Materials and methods A total of 23 patients (age 61 ± 2·5 years) with stable coronary artery disease and at least one haemodynamic significant stenosis eligible for percutaneous coronary intervention were prospectively recruited into the two study groups in a 2 : 1 manner (ECP : control). One group (ECP group, n = 16) underwent 35 1‐h sessions of ECP in 7 weeks. In the control group (n = 7), the natural course of collateral circulation over 7 weeks was evaluated. All patients underwent a cardiac catheterization at baseline and after 7 weeks, with invasive measurements of the pressure‐derived collateral flow index (CFIp, primary endpoint) and fractional flow reserve (FFR). Results In the ECP group, the CFIp (from 0·08 ± 0·01 to 0·15 ± 0·02; P < 0·001) and FFR (from 0·68 ± 0·03 to 0·79 ± 0·03; P = 0·001) improved significantly, while in the control group no change was observed. Only the ECP group showed a reduction of the Canadian Cardiovascular Society (CCS, P = 0·008) and New York Heart Association (NYHA, P < 0·001) classification. Conclusion In this study, we provide direct functional evidence for the stimulation of coronary arteriogenesis via ECP in patients with stable coronary artery disease. These data might open a novel noninvasive and preventive treatment avenue for patients with non‐acute vascular stenotic disease.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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