Fruits of Euterpe spp. are rich in phenolic compounds, mainly anthocyanins, which are endowed with a high antioxidant capacity. The objective of the study was to evaluate the effects of derivatives from Euterpe spp. fruits on oxidative metabolism and inflammatory mediators. The oil (OE), total lyophilized pulp (LEE) and defatted pulp (LEDE) were obtained from the fruits of Euterpe edulis. Thirty-six animals were divided into four experimental groups: G1: Control; G2: OE (4%), G3: LEE (10%), G4: LEDE (10%), each of which received a particular extract in their diet for 50 days. The activities of catalase, glutathione-S-transferase, superoxide dismutase, malondialdehyde produced in liver and expression of pro-inflammatory cytokines tissue were lower in G4 than in the other groups. The study indicates that dietary supplementation with extracts of E. edulis has no deleterious effects and may be beneficial, especially for LEDE extracts containing high concentrations of anthocyanin.